Tolperisone hydrochloride

Research use only, not for human use.

Tolperisone hydrochloride is a centrally acting muscle relaxant, is indicated for use in the treatment of pathologically increased tone of the cross-striated muscle caused by neurological diseases.

Tolperisone hydrochloride is a centrally acting muscle relaxant, is indicated for use in the treatment of pathologically increased tone of the cross-striated muscle caused by neurological diseases (damage of the pyramidal tract, multiple sclerosis, myelopathy, encephalomyelitis) and of spastic paralysis and other encephalopathies manifested with muscular dystonia.

Cell Cycle Analysis Cell Line:AGS, A375, 8505C, and RKO cells Concentration:100 μM Incubation Time:48 h Result:Induced cell cycle arrest in G2/M phase, and reduced the proportion of cells in S phase.Decreased the protein expression of Cyclin B1 and CDC25C, and increased the level of p21 and p-CDC25C.Western Blot Analysis Cell Line:AGS, A375, 8505C, and RKO cells Concentration:0-150 μM Incubation Time:12 h Result:Increased levels of cleaved caspase-3, cleaved PARP-1, and pro-apoptotic BCL-2 family member Bax.Increased the levels of p-eIF2α, ATF4, CHOP, and GRP78 in AGS and A375 cells.

Animal Model:rats with partial sciatic nerve ligation (pSNL) evoked neuropathic pain Dosage:25-100 mg/kg Administration:p.o.Result:Restored the developed mechanical allodynia 60, 120, and 180 min after treatment.Reduced elevated Cerebrospinal Fluid (CSF) glutamate level.

N-553

Membrane Transporter/Ion Channel

Sodium Channel

Sodium Channel

Neurological Disease

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3644-61-9

281.82

C16H24ClNO

>98% (HPLC)

Ethanol: 56 mg/mL (198.7 mM); Water: 56 mg/mL (198.7 mM); DMSO: 56 mg/mL (198.7 mM)

Cl.CC(CN1CCCCC1)C(=O)C1=CC=C(C)C=C1

——

(-20℃)

With Ice Pack

≥ 2 years